Effect of phycocyanin on expression of malondialdehyde and interferon-γ placental trophoblast cells models of preeclampsia rats

Preeclampsia is a "disease of theory" because the cause and pathophysiology preeclampsia still uncertain. In invasion trophoblast cells does not occur completely, spiral arteries undergo remodeling so it has component muscle elastic tissue, in addition to endothelial dysfunction characterized by reduced relaxation factor increased contraction resulting ischemia placenta The end result hypoxia, hypoxia condition that causes production free radicals large quantities. Free can damage all cellular biochemical components lipids taking lipid electrons cell membrane called peroxidation. Lipid peroxidation process produces several products including Malondialdehyde (MDA) also mediate proinflammatory cytokines such expenditure Interferon Gamma (IFN-γ). this study, researchers took form placental tissue paraffin blocks which have been made, on each block containing number 6 groups (30 paraffin). method used double staining with reading 3 field 200x magnification. On examination done TBARS analyzed immunoflourence rhodamine DAPI, while inspection IFN-γ preparations antibodies PE anti-rat IFN-γ, DAPI were using immunoflourence, then interpreted software imunoflow. Provision Phycocyanin study proved reduce levels MDA Interferon-γ. dose 40 ng / 100 gramss BB an effective decreases Interferon-γ levels, Because phycocyanin role as anti-inflammatory, antioxidant immunomodulatory. giving doses trigger increase cytokines. Further research needed protective effect human tissue.